Allopurinol is in a class of medications called xanthine oxidase inhibitors. It works by reducing the production of uric acid in the body. High levels of uric acid may cause gout attacks or kidney stones. Allopurinol is used to prevent gout attacks, not to treat them once they occur.
NSAIDs are the most commonly used drugs in acute gout. Over the long term, gout is treated by decreasing tissue stores of uric acid with the xanthine oxidase inhibitors allopurinol or febuxostat or with the uricosuric agent probenecid.
Furthermore, does allopurinol get you high? Take as directed. Allopurinol oral tablet is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed. If you stop taking the drug suddenly or don’t take it at all: The uric acid levels in your blood or urine will stay high.
Hereof, what is allopurinol taken?
Allopurinol is used to treat gout and certain types of kidney stones. It is also used to prevent increased uric acid levels in patients receiving cancer chemotherapy. These patients can have increased uric acid levels due to release of uric acid from the dying cancer cells.
Is allopurinol a diuretic?
Oftentimes, a diuretic can be restarted at a lower and sometimes still effective dose. In the process, careful attention should be paid to avoidance of excessive volume contraction. In the patient with preexisting gout and with a need for diuretic therapy, the xanthine oxidase inhibitor, allopurinol, can be considered.
Can you stop taking allopurinol?
Do not stop taking allopurinol suddenly unless you have a skin rash or allergic reaction. Speak to your doctor or nurse before stopping. Stopping allopurinol quickly can cause a flare up and make your gout worse.
Does allopurinol raise blood pressure?
Hyperuricemia has been shown to raise blood pressure (BP) in normotensive rats, and this rise is attenuated by urate-lowering drugs. In 1 study, both allopurinol (a xanthine oxidase inhibitor that reduces the formation of uric acid) and probenecid (a uricosuric drug) were studied.
Is allopurinol bad for the kidneys?
Allopurinol Safe Even With Chronic Kidney Disease. Allopurinol is a safe and effective therapy for lowering urate levels in gout, even in patients with creatinine clearances (CrCL) < 30 mL/min. High doses of allopurinol are rarely needed to achieve acceptable urate levels in patients with chronic kidney disease.
Should I take allopurinol in the morning or at night?
Allopurinol is usually taken once daily. However, if your dose is more than 300 mg, your doctor may advise you to take your medicine twice a day. Then, it should be taken morning and night, after breakfast and dinner.
Can allopurinol cause joint pain?
Allopurinol is used to prevent or lower high uric acid levels in the blood. A high uric acid level can cause gout or gouty arthritis (joint pain and inflammation).
How do you flush uric acid out of your body?
Apple Cider Vinegar: Mix one teaspoon of organic apple cider vinegar to a glass of water and drink this every day. Apple cider vinegar acts like a natural cleanser and detoxifier. It contains malic acid which helps in breaking down and removing uric acid from the body.
Can you drink alcohol with allopurinol?
Should I Avoid Any Food, Drink or Activity While Taking Allopurinol? Avoid drinking alcohol while taking allopurinol, as it may make your condition worse. Allopurinol may impair your thinking or reaction time, so you should be especially careful when driving or performing any activity that requires you to be alert.
Which is better colchicine or allopurinol?
Colchicine is used for acute flare ups of gout to act as an anti-inflammatory by reducing swelling and pain. Allopurinol is an antihyperuricemic which prevents the production of uric acid. Colchicine should be given in small doses to prevent side effects.
Is allopurinol bad for the liver?
Allopurinol may adversely affect liver function tests, most commonly manifesting as asymptomatic elevations of transaminases and/or alkaline phosphatase. However, a few cases of serious and sometimes fatal allopurinol-associated liver disease have been reported.
Do I have to take allopurinol forever?
It’s likely that you will need to take allopurinol for the rest of your life. You should keep taking allopurinol even: if you have more attacks of gout when you first start allopurinol. when you stop having attacks of gout – if you do this, your urate levels may start to build up again and your symptoms may return.
How long does it take for allopurinol to start working?
It can take 2-3 months to become fully effective. It does not have any effect during a gout attack, although you should continue to take it regularly every day even if this happens. During the first few weeks of taking allopurinol, your blood levels of uric acid may rise for a short while before they fall.
Can you buy allopurinol over the counter?
Your doctor may recommend one of these medicines that you can’t get over the counter: Allopurinol (Aloprim, Zyloprim)reduces uric acid production.
How safe is allopurinol?
The combined risk of adverse events was RR = 1.04 (95 % CI 0.98, 1.11). Allopurinol is a safe option, slightly better than other ULDs. The grade of evidence is high, but further research is needed to evaluate higher doses and long-term safety.
What does allopurinol do to your body?
Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones. Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment.